Metabolic Adaptations in Health and Disease

The overall goal of this research programme is to understand the metabolic adaptations during the life cycle in response to stress, in particular dietary stress, infection and inflammation; and the interplay with susceptibility to disease especially chronic non-communicable diseases such as diabetes and hypertension. This also extends to Sickle Cell Disease, whose phenotypic expression is modulated by level of inflammatory stress as well as the unique metabolic demand imposed by the chronic hemolytic state. It therefore provides a metabolic milieu to model the interaction between diet, health, inflammation, metabolic demands and disease outcomes. Understanding the limits of adaptation in these states will help us better mitigate the adverse outcomes by designing targeted interventions.

Projects

• Minerals in longevity and ageing-MILEAGE.